Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

This article outlines the struggle between the power of the health care professional and the rights of the individual to choose freely a modality of treatment. Nurses are instrumental in assisting patients in making the best decision for a therapy they will have to assume for the rest of their lives. In guiding patients' decision, nurses must take into account these unavoidable contingencies: changes in lifestyle, nutritional restrictions, level of acceptance, compliance issues, ease of training and availability of support/facilities. Ensuring (...) that the patient makes an informed decision is therefore an ongoing challenge for nurses as they are taking part in a delicate balancing act between not directly influencing the patient's decision while making sure the patient is accurately informed. (shrink)

This paper concludes a special feature of Sustainability Science that explores a broad range of social value theoretical traditions, such as religious studies, social psychology, indigenous knowledge, economics, sociology, and philosophy. We introduce a novel transdisciplinary conceptual framework that revolves around concepts of 'lenses' and 'tensions' to help navigate value diversity. First, we consider the notion of lenses: perspectives on value and valuation along diverse dimensions that describe what values focus on, how their sociality is envisioned, and what epistemic and (...) procedural assumptions are made. We characterise fourteen of such dimensions. This provides a foundation for exploration of seven areas of tension, between: (1) the values of individuals vs collectives; (2) values as discrete and held vs embedded and constructed; (3) value as static or changeable; (4) valuation as descriptive vs normative and transformative; (5) social vs relational values; (6) different rationalities and their relation to value integration; (7) degrees of acknowledgment of the role of power in navigating value conflicts. In doing so, we embrace the 'mess' of diversity, yet also provide a framework to organise this mess and support and encourage active transdisciplinary collaboration. We identify key research areas where such collaborations can be harnessed for sustainability transformation. Here it is crucial to understand how certain social value lenses are privileged over others and build capacity in decision-making for understanding and drawing on multiple value, epistemic and procedural lenses. (shrink)

What is it to be an agent? One influential line of thought, endorsed by G. E. M. Anscombe and David Velleman, among others, holds that agency depends on practical rationality—the ability to act for reasons, rather than being merely moved by causes. Over the past 25 years, Velleman has argued compellingly for a distinctive view of agency and the practical rationality with which he associates it. On Velleman’s conception, being an agent consists in having the capacity to be motivated by (...) a drive to act for reasons. Your bodily movements qualify as genuine actions insofar as they are motivated in part by your desire to behave in a way that makes sense to yourself. However, there are at least two distinct ways of spelling out what this drive towards self-intelligibility consists in, both present in Velleman’s work. It might consist in a drive towards intelligibility in causal-psychological terms: roughly, a drive to maximize the rational coherence of your psychological states. Alternatively, it might consist in a drive towards narrative intelligibility: a drive to make your ongoing activity conform to a recognizable narrative structure, where that structure is understood emotionally. Velleman originally saw these options as basically equivalent, but later came to prioritize the drive towards causal-psychological intelligibility over that towards narrative intelligibility. I argue that this gets things the wrong way round—we should instead understand our capacities to render ourselves intelligible in causal-psychological terms as built upon a bedrock of emotionally suffused narrative understanding. In doing so, we resolve several problems for Velleman’s view, and pave the way for an embodied, embedded and affective account of practical rationality and agency. According to the picture that emerges, practical rationality is essential to agency, narrative understanding is essential to practical rationality, and the rhythms and structures patterning the ebb and flow of our emotional lives are essential to narrative understanding. (shrink)

This paper concludes a special feature of Sustainability Science that explores a broad range of social value theoretical traditions, such as religious studies, social psychology, indigenous knowledge, economics, sociology, and philosophy. We introduce a novel transdisciplinary conceptual framework that revolves around concepts of ‘lenses’ and ‘tensions’ to help navigate value diversity. First, we consider the notion of lenses: perspectives on value and valuation along diverse dimensions that describe what values focus on, how their sociality is envisioned, and what epistemic and (...) procedural assumptions are made. We characterise fourteen of such dimensions. This provides a foundation for exploration of seven areas of tension, between: (1) the values of individuals vs collectives; (2) values as discrete and held vs embedded and constructed; (3) value as static or changeable; (4) valuation as descriptive vs normative and transformative; (5) social vs relational values; (6) different rationalities and their relation to value integration; (7) degrees of acknowledgment of the role of power in navigating value conflicts. In doing so, we embrace the ‘mess’ of diversity, yet also provide a framework to organise this mess and support and encourage active transdisciplinary collaboration. We identify key research areas where such collaborations can be harnessed for sustainability transformation. Here it is crucial to understand how certain social value lenses are privileged over others and build capacity in decision-making for understanding and drawing on multiple value, epistemic and procedural lenses. (shrink)

This anthology takes the ever-controversial discussion of pornography out of solely academic circles; it expands the questions about porn that academics might tackle and opens the conversation to those who know it best—the creators and users of porn. Features essays on non-traditional issues in porn, including celebrity sex tapes, virtual sex, S&M, homosexual porn, and technology’s impact on the porn industry Features fascinating insights from psychologists, a lawyer, and an English professor, as well as industry insiders such as Dylan Ryder (...) A fun, entertaining, and philosophically provocative approach to pornography, written for the general reader. (shrink)

This is the first comprehensive study of Nietzsche's earliest (and extraordinary) book, The Birth of Tragedy (1872). When he wrote it, Nietzsche was a Greek scholar, a friend and champion of Wagner, and a philosopher in the making. His book has been very influential and widely read, but has always posed great difficulties for readers because of the particular way Nietzsche brings his ancient and modern interests together. The proper appreciation of such a work requires access to ideas that cross (...) the boundaries of conventional specialisms. This is now provided by M. S. Silk and J. P. Stern in their joint study of Nietzsche's book. They examine in detail its content, style and form; its strange genesis and hybrid status; its biographical background and the controversy engendered by its publication; its value as an account of ancient Greek culture and as a theory of tragedy and music; its relation to other theories of tragedy; and its place in the history of German ideas and in Nietzsche's own philosophical career. (shrink)

Background. The COVID-19 pandemic necessitated drastic changes to undergraduate medical training at the University of Botswana (UB). To save the academic year when campus was locked down, the Department of Medical Education conducted a needs assessment to determine the readiness for emergency remote teaching (ERT) of the Faculty of Medicine, UB. Objectives. To report on the findings of needs assessment surveys to assess learner and teaching staff preparedness for fair and just ERT, as defined by philosopher John Rawls. Methods. Needs (...) assessment surveys were conducted using Office 365 Forms distributed via WhatsApp, targeting medical students and teaching staff during the 5 undergraduate years. Data were analysed quantitatively and qualitatively. Results. Ninety-two percent (266/289) of students and 73.5% (62/84) of teaching staff responded. Surveys revealed a high penetration of smartphones among students, but poor internet accessibility and affordability in homes. Some teaching staff also reported internet and device insufficiencies. Only WhatsApp was accessible to students and teaching staff. Conclusions. For equitable access to ERT in the future, the surveys revealed infrastructural improvement needs, including wider, stronger, affordable WiFi coverage within Botswana and enhanced digital infrastructures in educational institutions, with increased support for students. (shrink)

Zhizneopisanie -- Kniga znanii︠a︡ -- Ukazanii︠a︡ i nastavlenii︠a︡ -- Kniga o dushe.

Consider orthodox motivational judgment internalism: necessarily, A’s sincere moral judgment that he or she ought to φ motivates A to φ. Such principles fail because they cannot accommodate the amoralist, or one who renders moral judgments without any corresponding motivation. The orthodox alternative, externalism, posits only contingent relations between moral judgment and motivation. In response I first revive conceptual internalism by offering some modifications on the amoralist case to show that certain community-wide motivational failures are not conceptually possible. Second, I (...) introduce a theory of moral motivation that supplements the intuitive responses to different amoralist cases. According to moral judgment purposivism (MJP), in rough approximation, a purpose of moral judgments is to motivate corresponding behaviors such that a mental state without this purpose is not a moral judgment. MJP is consistent with conceptual desiderata, provides an illuminating analysis of amoralist cases, and offers a step forward in the internalist-externalist debates. (shrink)

Several gaze contingent studies that used a fixed delay between physical eye movements and a display change documented a dip in the fixation duration distributions (e.g., Blanchard et al. 1984; McConkie et al. 1985; van Diepen et al. 1995). In a study by van Diepen et al. (1995), a moving mask paradigm was employed in which subjects searched line drawings of everyday scenes for non-objects. The appearance of the mask was delayed relative to the end of a saccade (beginning of (...) fixation) by 17, 46, 76 or 121 msec. All fixation duration distributions in the masking conditions exhibited a dip with longer masking delays resulting in the dip occurring at longer fixation durations. In contrast, a no-mask condition did not produce a dip. Similar effects in reading were reported by Blanchard et al. (1984), and McConkie et al. (1985). In both these studies the text was.. (shrink)

In 5 experiments, participants read text that was briefly replaced by a transient image for 33 ms at random intervals. A decrease in saccadic frequency, referred to as saccadic inhibition, occurred as early as 60 –70 ms following the onset of abrupt changes in visual input. It was demonstrated that the saccadic inhibition was influenced by the saliency of the visual event (Experiment 3) and was not produced in response to abrupt but irrelevant auditory stimuli (Experiment 1). Display changes restricted (...) to an area either inside or outside the perceptual span required for normal reading produced strong saccadic inhibition (Experiment 2). Finally, Experiments 4 and 5 demonstrated higher level cognitive or attentional modulation of the saccadic inhibition effect. (shrink)

& The present study investigated saccadic inhibition in both voluntary and stimulus-elicited saccades. Two experiments examined saccadic inhibition caused by an irrelevant flash occurring subsequent to target onset. In each trial, participants were required to perform a single saccade following the presentation of a black target on a gray background, 48 to the left or to the right of screen center. In some trials (flash trials), after a variable delay, a 33-msec flash was displayed at the top and bottom third (...) of the monitor (these regions turned white). In all experimental conditions, histograms of flash-to-saccade latencies documented a decrease in saccadic frequency, forming a dip, time-locked to the flash and occurring as early as 60–70 msec following its onset. The fast latency of this effect strongly suggests a low-level, reflex-like, oculomotor effect, which was referred to as saccadic inhibition. A novel procedure was developed to allow comparisons of saccadic inhibition even across conditions, which in the absence of a flash (no-. (shrink)

Gordon Baker and I had been colleagues at St John’s for almost ten years when we resolved, in 1976, to undertake the task of writing a commentary on Wittgenstein’s Philosophical Investigations. We had been talking about Wittgenstein since 1969, and when we cooperated in writing a long critical notice on the Philosophical Grammar in 1975, we found that working together was mutually instructive, intellectually stimulating and great fun. We thought that we still had much to say about Wittgenstein’s philosophy, and (...) it seemed to us that misinterpretations of passages in the Investigations were so extensive that it would be worth trying to write a detailed analytical commentary. It is difficult to recapture the excitement of those early days in being among the first to work on the microfilms and, subsequently, on the photocopies of Wittgenstein’s Nachlass. We spent many hundreds of hours poring over the typescripts and the often only semi-legible manuscripts, fascinated and privileged to be able to try to follow the development of the thoughts of a great philosophical genius. We talked endlessly about what we had found in Wittgenstein’s manuscripts and typescripts, and debated how it should be understood. The first fruit of our labours was Wittgenstein – Understanding and Meaning. Its guiding idea was to draw attention to the manner in which Wittgenstein linked the concepts of meaning, understanding and explanation, and so to bypass the connections between meaning, truth and truth-conditions that so fascinated philosophers of the 1970s, and to abandon the red-herring of assertion-conditions and anti-realism. After a hiatus of four years, during which time we wrote a controversial book entitled Frege – Logical Excavations and a polemical book on contemporary philosophy of language – Language, Sense. (shrink)

Sympathy, empathy, and compassion are strands in the network of love and essential corollaries of friendship. Together with love and friendship, they are the saving graces of mankind. This chapter aims to clarify the relationship between sympathy and empathy. It may be helpful first to list the relevant dispositions, tendencies, powers, and feelings. The most important contributions to the analysis of sympathy were Hume's A Treatise of Human Nature and Adam Smith's The Theory of Moral Sentiments. It was they who (...) provided the first extensive phenomenological description and philosophical anatomy of sympathy. It is noteworthy that Theodor Lipps had translated Hume's Treatise into German. His account of empathy had its roots in Hume's projectivism. With the demise of behaviourism in the 1970s, the notion of empathy became an object for reflections of experimental and practical psychologists and therapists. (shrink)

This chapter contains section titled: Baker's New Conception Waismann and Wittgenstein Wittgenstein on the Psychoanalytic Analogy Wittgenstein's Methodology Reconsidered Wittgenstein and Ryle 1: Categorial Confusions Wittgenstein and Ryle 2: Logical Geography Baker's Wittgenstein.

Jealousy often wreaks havoc among those who love each other. There are many different forms of jealousy. These can be brought to light by scrutiny of grammar, which discloses the scope and limits of the concept of jealousy and hence too of the emotion it subsumes. In Bronzino's painting, Jealousy has a livid complexion (a mixture of yellow and black bile). Robert Herrick's poem in Anthony Frederick Sandys's painting, however, associates jealousy with yellow. In this, he too was following the (...) doctrine of the humours, which explained jealousy by reference to an excess of the choleric humour of yellow bile that causes anger, irritability, boldness, envy, jealousy, and courage. The chapter elaborates the manifold differences between two emotions, envy and jealousy, and the corresponding character traits and motives. The comparison involves numerous for the most parts, and normallys. (shrink)

Given the ubiquity of the phenomena of anger and the roots of the emotion in the animal nature, it is not surprising that human languages have a rich vocabulary to express, report, describe, and evaluate the various manifestations and expressions of anger. Different cultures and different languages have evolved their distinctive orgetic vocabularies. This chapter is concerned with the family of concepts of anger, as expressed in English. The doctrine of the humours is reflected in the iconography of anger. Eichler's (...) engraved illustration for Ripa's iconological analysis of Cholericus depicts an angry youth – for the young, Ripa explained, like the choleric, lack judgement. The chapter discusses the physiognomy, behavioural manifestations, and verbal expressions of anger. So much for the connective analysis of anger. People's understanding of the place of anger in human life can be deepened and enriched by scrutiny of some of the ancient literary and philosophical descriptions and analyses of the phenomena. (shrink)

The distinction between shame cultures and guilt cultures is due to the anthropologist Ruth Benedict. The moral education of the youth in a shame culture will involve a multitude of prescriptions determining how to conduct oneself. Heroic societies with a closed aristocratic warrior class are typically shame cultures. The form of the dominant norms of a guilt culture is the imperative or dominative tense, which determines what one is obligated to do. This is the typical form of the obligation‐imposing commandments (...) of God. A primary focus of shame in the emerging guilt culture became sexuality and the body, and shame became forcefully riveted to the notion of sin. Feeling shame, like feeling pride, lies at the centre of a ramifying cluster of emotions and emotional attitudes. Shame bears a kinship to embarrassment. Embarrassment is distinguished from feeling shame in so far as it is essentially an audience‐involving emotion. (shrink)

Human emotions are passions – ways in which the soul is affected. It is noteworthy that the Cartesian conception, especially in its concern with the physiology of the emotions and with their causal order, inspires neuroscientific investigation of the emotions to this day. A detailed empiricist account of the character of the concepts of the emotions and of their mode of acquisition is to be found in the writings of John Locke. In his view, all ideas are derived either from (...) sensation or from reflection. The most influential psychological account of the emotions advanced in the late nineteenth century was the James‐Lange theory. It dominated reflection upon the emotions among experimental psychologists until the rise of behaviourism, and it again had a substantial influence towards the end of the twentieth century upon the somatic marker theory of the emotions advanced by the cognitive neuroscientist Antonio Damasio. (shrink)

In antiquity the subject of friendship occupied centre stage in discussions of the good life. Friendship is possible between people who are not equals in virtue, status, power, or intellect, but then, Aristotle argues, it is a less than perfect form of friendship. Friendship is a focal concept, the focus of which is the friendship of men of excellence and virtue who are, in relevant respects, equals. Aristotle's detailed investigations of friendship in the Nicomachean Ethics set the stage and determined (...) the questions to be addressed in all subsequent discussions. The abstract noun philia brackets both love and friendship. Aristotle argued that the origins of philia lie in the household. This chapter discusses prominent characteristics of friendship. It is believed that friendship is a relationship, not an emotion. That relationship may be deep or superficial (casual), depending upon the strength and depth of the feelings that obtain. (shrink)

Each person should have their pride – a proper sense of their worth and dignity. Improper pride is arrogance; proper pride, one might say, is necessary for self‐respect. As an emotion, pride may take the form of a momentary emotional occurrence, as when, for example, one is complimented by people whose approval one appreciates on some achievement of one's own, of one's spouse, or of one's children. Pride may also take the form of a persistent, enduring, emotion, as when one (...) feels proud of one's beauty and figure, or of the good looks of one's spouse or children; of one's achievements; of some admirable possession one owns; of one's dog or horse; and of one's high rank and office. Christian theologians have taken certain forms of pride to be contraries, the former a deadly vice and the latter a virtue. Hume too took pride and humility to be contraries. (shrink)

Manifestations and expressions of emotion are elements of an ensemble of immediate reactive and responsive behaviour, emotion‐eliciting situation, past relationships and events, persistent emotions exhibited in intentional and emotionally motivated speech and action. These elements form, and reform, highly complex patterns – but, like the patterns of tribal carpets, the patterns display varying degrees of irregularity and asymmetry, which vary from rug to rug. The constitutional indeterminacy of the emotions, of their depth and authenticity, and of the motives to which (...) they give rise is part of the human condition. Susceptibility to emotions is a feature of advanced forms of animal life. For one's emotions should be felt for the right reasons, directed at the right objects, made manifest and expressed on the right occasions, and felt to the right degree. Then one's emotions are reasonable and justifiable, even though people cannot feel an emotion at will. (shrink)

Actions done out of jealousy or envy are vicious. The corresponding character traits – having a jealous or envious disposition – are vices. Envy motivates ever greater efforts in the pursuit of private wealth, and, coupled with greed and covetousness, stimulates acquisitive competition, thus benefiting the economy. Envy is often linked to Schadenfreude. Jealousy characteristically involves hostility if not hatred towards the person who is taking away the love one feels is due to one, and engenders bitterness, hostility, or hatred (...) towards the person one loved. Like many emotions, envy and jealousy provide motives for action. For in both cases there are characteristic patterns of backward‐ and forward‐looking reasons for action. There are numerous biblical tales to illustrate the evils of envy, and others that demonstrate the vice of jealousy. For the most part, qin'ah is condemned as a serious and self‐destructive vice. (shrink)

The manifold phenomena of love exhibited in diverse human societies during different periods of recorded history are rooted in biological features of human beings. The human procreative urge among women is natural to our species. Maternal love is rooted in mammalian nature. The ideal love of a mother for her child is a common transcultural paradigm of selflessness. This chapter first examines the biological roots of love and subsequently to the social constraints within which its various forms are possible. It (...) then discusses the multiple kinds of possible objects of love and the threads connecting them, and explains the framework of moral, social, and legal norms within which human love is realized. Love is a paradigm of a developing emotion. Being in love is the natural sequel to falling in love. It involves wanting to be with the person loved, a strong desire to please, to share experience, and to delight in shared experiences. (shrink)

The emotions distinctive of human beings, as opposed to other animals, are emotions that presuppose possession of a language and hence powers of intellect and rational will. The objects distinctive of human emotions presuppose mastery of a language and possession of rational abilities. Music itself has been considered to be the purest artistic expression of human emotions and of the striving of the human will. The emotions, in particular temporary emotions, have characteristic multiple associations, manifestations, and forms of expression. This (...) chapter distinguishes between the neural/physiological and somatic associations, on the one hand, and the behavioural manifestations and verbal expressions of the emotions, on the other. Behavioural manifestations and expressions of emotion and emotionally motivated actions lie along a volitional spectrum that ranges from the non‐voluntary to the involuntary, and from the voluntary but not intentional to the intentional and deliberate. (shrink)

Passions subsumes the natural human appetites (hunger, thirst, lust, and addictions); felt desires, such as urges, cravings, and impulses; some obsessions (obsessive emotions and compulsive obsessions); and the affections (agitations, moods, and emotions) of a living being. It is important to clarify the concept of emotion that is to locate it among the concepts of the passions thus construed, and to describe the differences between emotions and other passions. This chapter describes the conceptual boundaries that distinguish the emotions from other (...) affections, such as agitations and moods; from felt desires, such as urges and cravings; from obsessions and appetites; and also from attitudes. Emotions are classified as negative or positive, according as to whether one would (normally) prefer to feel such emotions (delighted, excited, overjoyed, contented, amused, affection), or prefer not to be subjected to them (feeling bored, envious, jealous, frightened, sorrow, embarrassed, humiliated). (shrink)

"Plato's Statesman reconsiders many questions familiar to readers of the Republic: questions in political theory - such as the qualifications for the leadership of a state and the best from of constitution (politeia) - as well as questions of philosophical methodology and epistemology. Instead of the theory of Forms that is the centrepiece of the epistemology of the Republic, the emphasis here is on the dialectical practice of collection and division (diairesis), in whose service the interlocutors also deploy the ancillary (...) methods of myth and of models (paradeigmata). Plato here introduces the doctrine of due measure (to metrion) and a conception of statecraft (politikē) as an architectonic expertise that governs subordinate disciplines such as rhetoric and the military - doctrines later developed by Aristotle. Readers will find a sustained defence of the importance of expertise (technē or epistēmē) in the conduct of affairs of state, a robust (although not unqualified) defence of the rule of law, and an unsparing but nuanced critique of democratic government. The chapters in this volume provide a comprehensive and detailed philosophical engagement with the entirety of Plato's wide-ranging dialogue, with successive chapters devoted to the sections of the dialogue as it unfolds, and an introduction that places the dialogue in the context of Plato's philosophy as a whole. While not a commentary in the traditional sense, the volume engages with Plato's Statesman in its entirety" -- Publisher's description. (shrink)

Throughout its long history metaphysics has been variously conceived. At its most sublime, it has been taken to be the study of the super‐sensible, in particular of the existence of a god, the nature of the soul, and the possibility of an afterlife. When the young Ludwig Wittgenstein entered the lists, it was entirely reasonable to conceive of metaphysics in this manner. Its subject matter was held to be the language‐independent and thought‐independent de re necessities of the world. The Tractatus (...) is dominated by three problems: first, the nature of logic and logical necessity; secondly, the essence of the proposition and hence the characterization of the general propositional form; and thirdly, the intentionality of the proposition. Logical propositions are combinations of elementary propositions by means of truth‐functional logical connectives. The metaphysics adumbrated in the Tractatus, Wittgenstein thought, was required for the possibility of representation and for the possibility of logic. (shrink)

... 243-) INTRODUCTION §§243- constitute the eighth 'chapter' of the book. Its point of departure is a natural query with respect to the conclusion of the ...

The body of the one deemed mad often remains a sexual body with sexual needs. Mental health services respond to these demands of the body in various ways, including constructing rules around physical movement. In this context, we were interested in how mental health clinicians problematized the sexual needs and practices of residents of a long‐stay mental health rehabilitation facility and how solutions were constructed in relation to the residents’ sexual desires. This paper reports findings from mental health clinicians, as (...) part of a case study where we addressed this question. Mental health clinicians responded to residents’ sexuality from a discourse of risk. The notion of the engagement with each resident as a sexual subject was subordinated to the paternalistic notion of protecting the patient from risk. The resident became an object to be monitored and protected rather than a subject with sexual desire and agency. This paternalism also showed itself in relation to a ‘no‐sex on‐site’ rule that allowed for a shift of risk from the organization to the resident. Residents, rather than having a relatively safe place to have sexual relations, were required to find a place elsewhere, potentially unsafe, outside the facility. (shrink)